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Anticoagulants
Warfarin - Vitamin K antagonist [Coumadin, Marevan]
Indication: VTE, Thromboembolic risk in AF, heart valves and stroke
Typical dose: 1 - 10mg OD depending on INR (range 2-3)
Max daily dose: 10mg OD
Contraindications: Alcoholism
Interactions: Cranberry juice, Vitamin K, Amiodarone, NSAIDs, St. John's Wort
Referral: Blood in urine or faeces, purple bruises
Counselling:
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Take at same time each day
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Always take same brand of tablets
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Avoid excess alcohol
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Warning bracelet
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Pregnancy: D
Apixaban - Factor Xa Inhibitor [Eliquis]
Indication: Prevention of VTE following hip or knee replacement, AF, Systemic embolism
Typical dose: 2.5 - 5mg BD
Max daily dose: 5mg BD
Contraindications: Ritonavir, Ketoconazole, Rifampicin
Interactions: Blood thinners
Referral: Bleeding (e.g Signs of anaemia)
Counselling:
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Take at same time each day
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Warning bracelet
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Pregnancy: C
Rivaroxaban - Factor Xa Inhibitor [Xarelto]
Indication: VTE and VTE following hip or knee replacement, AF, Systemic embolism
Typical dose: 10 - 20mg OD
Max daily dose: 20mg OD
Contraindications: Ritonavir, Ketoconazole, Rifampicin
Interactions: Blood thinners
Referral: Bleeding (e.g Signs of anaemia)
Counselling:
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Take at same time each day with food
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Warning bracelet
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Pregnancy: C